Speed Switch in Glioblastoma Growth Rate due to Enhanced Hypoxia-Induced Migration
نویسندگان
چکیده
منابع مشابه
Involvement of Drp1 in hypoxia-induced migration of human glioblastoma U251 cells.
Glioblastoma is one of the most aggressive brain tumors with high morbidity and mortality. Hypoxia is often the common characteristic of tumor microenvironment, and hypoxia-inducible factor-1α (HIF-1α) is an essential factor regulating the migratory activity of cancer cells including glioblastoma. Recently, mitochondrial dynamics was found to be involved in the aggression of cancer cells. Howev...
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This corrects the article DOI: 10.1038/ncomms13428.
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Hypoxia strongly up-regulates tissue factor and promotes plasma clotting by glioblastoma multiforme, but transcriptional mechanisms remain undefined. Here, we investigated the potential roles of early growth response gene-1 (Egr-1), Sp1, nuclear factor-KB (NF-KB), activator protein-1 (AP-1), and hypoxia-inducible factor-1 (HIF-1) in the hypoxic regulation of tissue factor by glioblastoma multif...
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ژورنال
عنوان ژورنال: Bulletin of Mathematical Biology
سال: 2020
ISSN: 0092-8240,1522-9602
DOI: 10.1007/s11538-020-00718-x